学術誌に掲載されている
様々な研究論文
これまでゴールデンバイオテック社は、アントロキノノールの研究において、２７回にわたり国際学術誌で研究成果を発表してきました。期間については２０年以上にわたっており、決して短期的な研究によるものではなく、長期にわたり地道に研究が行われてきていることがご理解いただけます。代表的な論文誌およびこれまで発表されてきた具体的な研究テーマの一部を公開します。
代表的な論文誌
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PLOS ONE誌
刊行：Public Library of Science社
特徴：オープンアクセス(OA)の査読つきの科学雑誌（※１） -
Scientific Reports誌
刊行：Nature Reserch社
特徴：オープンアクセス（OA）の学術雑誌であり、科学的正統性のみを評価する雑誌。世界最大の学術雑誌でもある。 -
Biomedicine &
Pharmacotherapy誌刊行：Elsevier社
特徴：薬の効果に特化した査読付きの医学雑誌。 -
Mutation Reserch誌
刊行：Elsevier社
特徴：遺伝子に焦点を当てた査読付き科学誌。
※１ オープンアクセスとは、論文が誰でも無料で閲覧できる仕組みを指し、査読は、その公開前に論文の質を保証するために行われる評価プロセスのことを指します。
ゴールデンバイオテック社が
これまで発表してきた論文の一部
| 学術誌 | テーマ |
|---|---|
| Planta Medica | A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata. |
| Biochemical Pharmacology | Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. |
| EBCAM | An Extract of Antrodia camphorata Mycelia Attenuates the Progression of Nephritis in Systemic Lupus Erythematosus-Prone NZB/W F1 Mice. |
| Mutation Research | Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles. |
| Journal of Ethnopharmacology | Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation. |
| Arthritis & Rheumatology | Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis. |
| Journal of Nutritional Biochemistry | Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis,autophagy and senescence in human pancreatic carcinoma cells. |
| Free Radical Biology and Medicine | Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome. |
| Biomedicine & Pharmacotherapy | Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells. |
| British Journal of Pharmacology | Synthetic (+)-antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities |
| Food and Chemical Toxicology | Antroquinonol from Antrodia camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions. |
| Scientific Reports | Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. |
| Molecular and Clinical Oncology | A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen. |
| PLOS one | Antroquinonol Targets FAK-Signaling Pathway Suppressed Cell Migration, Invasion, and Tumor Growth of C6 Glioma |
| Journal of Agricultural and Food Chemistry | Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets. |